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신경이 괴사한 치아는 이미 제 기능을 하지 못하고 통증을 생성하기 때문에 필히 처치가 요구된다. 피부까지 병변이 생겼다면 이미 치근단 주위는 염증현상이 상당히 진행된 상황여서 해당 치아를 발치하고 주위 염증 부위까지 깔끔하게 제거하는 것도 고려해야한다.

치수에 염증 또는 괴사가 발생하면 보통 치근단 영역으로 확대되면서 치근단에 병소가 발생한다. 병소가 눈 아래쪽에 있는 제4전구치 뿌리에 생성하면 초기에는 염증성 농이 내보내지 못해 눈 밑이 부어오르고 농이 계속 축적되다 피부가 밖으로 터져서 나오게 되는 것이다.

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