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발기부전은 특출난 질병이 없다면 원인적으로는 성기 부위로의 혈류 순환 장애로 발생한다. 실제로 발기부전 병자는 건강인에 비해서 심혈관 질환 발생 위험과 사망률이 더 높다. 발기부전 치료제는 성기 혈관 내 혈류를 증가시키는 약제이며, 대표적인 것이 비아그라, 시알리스 등이 포함되는 비아그라류와 알프로스타딜이 함유된 프로스타글란딘 제제이다.